Creating an effective policy environment, capable of exploiting the potential that science and technology offers, will require innovative ways to engage smallholders to become better informed and more active participants in markets, policy processes and priority setting in agricultural research and development. African countries need increased capacity to address product quality, comply with biosafety standards and phytosanitary requirements, and work with regulatory regimes related to GMOs. They also need the skills to negotiate effectively with OECD-importing countries. Only then will the private sector express its unrealized potential to contribute to the agricultural productivity recovery.